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The review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews like this one draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic. The studies, which looked at 540 patients, measured the effectiveness of several treatments, including topical and oral corticosteroids and topical cyclosporine. These drugs dampen the immune system to try to stop it from becoming confused and attacking the body. Other treatments examined in the studies include photodynamic therapy (which exposes the skin to light) and topical minoxidil (Rogaine).

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The researchers could not find any randomized controlled studies of other treatments, including diphencyprone, dinitrochlorobenzene, intralesional corticosteroids and dithranol. According to the review, none of the studies showed long-term beneficial hair growth - the return of more than half of the missing hair. Few treatments for alopecia areata have been well evaluated in randomized trials and we found none that addressed participant-focused measures of success or measurements of quality of life, the review authors wrote. The reviewers had hoped to look at 11 other studies, but were not able to do so. In some cases, the researchers could not obtain copies of the studies. In others, the studies have not yet been published. One small, unpublished study found that hair regrew in almost half of 60 subjects who applied onion juice to their heads. They all had mild cases of the condition affecting less than a quarter of their heads.

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